1. Appetite Loss – HIV/AIDS
   

2. Studies & Case Studies
   

3. Controlled Studies
   

4. Dronabinol
   

5. •     Beal JE, Olson R, Laubenstein L, Morales JP, Bellman P, Yangco B, Lefkowitz L, Plasse TF, Shepard KV. Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. Journal of Pain and Symptom Management 1995;10(2):89-97.
   

6. •     Timpone JG, Wright DJ, Li N, Egorin MJ, Enama ME, Mayers J, Galetto G, and the DATRI 004 Study Group. The safety and pharmacokinetics of single-agent and combination therapy with megestrol acetate and dronabinol for the treatment of HIV wasting syndrome. AIDS Research and Human Retroviruses 1997;13:305-315.
   

7. •     Abrams DI, Hilton JF, Leiser RJ, Shade SB, Elbeik TA, Aweeka FT, Benowitz NL, Bredt BM, Kosel B, Aberg JA, Deeks SG, Mitchell TF, Mulligan K, Bacchetti P, McCune JM, Schambelan M. Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial. Ann Intern Med 2003;139(4):258-66.
   

8. •     Haney M, Rabkin J, Gunderson E, Foltin RW. Dronabinol and marijuana in HIV(+) marijuana smokers: acute effects on caloric intake and mood. Psychopharmacology (Berl) 2005;181(1):170-8.
   

9. •     Haney M, Gunderson EW, Rabkin J, Hart CL, Vosburg SK, Comer SD, Foltin RW. Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep. J Acquir Immune Defic Syndr 2007;45(5):545-54.
   

10. Cannabis (smoked)
    

11. •      Haney M, Rabkin J, Gunderson E, Foltin RW. Dronabinol and marijuana in HIV(+) marijuana smokers: acute effects on caloric intake and mood. Psychopharmacology (Berl) 2005;181(1):170-8.
    

12. •     Haney M, Gunderson EW, Rabkin J, Hart CL, Vosburg SK, Comer SD, Foltin RW. Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep. J Acquir Immune Defic Syndr 2007;45(5):545-54.
    

13.  
    

14. Uncontrolled Studies
    

15. Dronabinol
    

16. •     Gorter R, Seefried M, Volberding P. Dronabinol effects on weight in patients with HIV infection. AIDS 1992;6:127.
    

17. •     Plasse TF, Gorter RW, Krasnow SH, Lane M, Shepard KV, Wadleigh RG. Recent clinical experience with dronabinol. Pharmacology, Biochemistry and Behavior 1991;40:695-700.
    

18. •     Plasse T, Conant M, Gorter R, Shepard KV. Dronabinol stimulates appetite and causes weight gain in HIV patients. International Conference on AIDS 1992;8(3):122 (abstract no. PuB 7442).
    

19. •     Struwe M, Kaempfer SH, Geiger CJ, Pavia AT, Plasse TF, Shepard KV, Ries K, Evans TG. Effect of dronabinol on nutritional status in HIV infection. Annals of Pharmacotherapy 1993;27:827-831.
    

20. •     Beal JE, Olson R, Lefkowitz L, Laubenstein L, Bellman P, Yangco B, Morales JO, Murphy R, Powderly W, Plasse TF, Mosdell KW, Shepard KV. Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia. Journal of Pain and Symptom Management 1997;14(1):7-14.
    

21. •     Dejesus E, Rodwick BM, Bowers D, Cohen CJ, Pearce D. Use of dronabinol improves appetite and reverses weight loss in HIV/AIDS-infected patients. J Int Assoc Physicians AIDS Care 2007;6(2):95-100.
    

22.  
    

23. Case Reports, Surveys
    

24. Cannabis (smoked)
    

25. •      Prentiss D, Power R, Balmas G, Tzuang G, Israelski DM. Patterns of marijuana use among patients with HIV/AIDS followed in a public health care setting. J Acquir Immune Defic Syndr 2004;35(1):38-45.
    

26. •     Woolridge E, Barton S, Samuel J, Osorio J, Dougherty A, Holdcroft A. Cannabis use in HIV for pain and other medical symptoms. J Pain Symptom Manage 2005;29(4):358-67.
    

27. •     Sidney S. Marijuana use in HIV-positive and AIDS patients: Results of a an anonymous mail survey. J Cannabis Ther 2001;1(3-4):35-43.
    

28.  
    

29. Appetite Loss – Cancer
    

30. Controlled Studies
    

31. Dronabinol
    

32. •      Jatoi A, Windschitl HE, Loprinzi CL, Sloan JA, Dakhil SR, Mailliard JA, Pundaleeka S, Kardinal CG, Fitch TR, Krook JE, Novotny PJ, Christensen B. Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study. Journal of Clinical Oncology 2002;20(2):567-573.
    

33. •     Regelson W, Butler JR, Schulz J, Kirk T, Peek L, Green ML, Zalis MO. Delta-9-tetrahydro­cannabi­nol as an effective antidepressant and appetite-stimulating agent in ad­vanced cancer pa­tients. In: Braude MC, Szara S, editors. Pharmacology of mari­hu­ana. Vol 2. New York: Ra­ven Press, 1976. p. 763-776.
    

34. •     Wadleigh R, Spaulding GM, Lumbersky B, Zimmer M, Shepard K, Plasse T. Dronabinol enhancement of appetite in cancer patients. Proc Am Soc Oncology 1990; 9: 331.
    

35. •      Strasser F, Luftner D, Possinger K, Ernst G, Ruhstaller T, Meissner W, Ko YD, Schnelle M, Reif M, Cerny T. Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-in-Cachexia-Study-Group. J Clin Oncol 2006;24(21):3394-400.
    

36. Cannabis (oral, sublingual)
    

37. •      Strasser F, Luftner D, Possinger K, Ernst G, Ruhstaller T, Meissner W, Ko YD, Schnelle M, Reif M, Cerny T. Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-in-Cachexia-Study-Group. J Clin Oncol 2006;24(21):3394-400.
    

38.  
    

39. Uncontrolled Studies
    

40. Dronabinol
    

41. •      Plasse TF, Gorter RW, Krasnow SH, Lane M, Shepard KV, Wadleigh RG. Recent clinical experience with dronabinol. Pharmacology, Biochemistry and Behavior 1991;40:695-700.
    

42. •      Nelson K, Walsh D, Deeter P, Sheehan F. A phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia. Journal of Palliative Care 1994;10:14-18.
    

43.  
    

44. Appetite Loss – Alzheimer's Disease
    

45. Controlled Studies
    

46. Dronabinol
    

47. •          Volicer L, Stelly M, Morris J, McLaughlin J, Volicer BJ. Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease. International Journal of Geriatric Psychiatry 1997;12:913-919.
    

48.  
    

49. Uncontrolled Studies
    

50. Dronabinol
    

51. •     Patel S, Shua-Haim JR, Pass M. Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia: A retrospective chart review. Abstract, 11th International Conference of the IPA, 17-22 August 2003, Chicago.
    

52.  
    

53. Appetite Loss – Geriatrics
    

54. Uncontrolled Studies
    

55. Dronabinol
    

56. •      Wilson MM, Philpot C, Morley JE. Anorexia of aging in long term care: is dronabinol an effective appetite stimulant? - a pilot study. J Nutr Health Aging 2007;11(2):195-8.
    

57.  
    

58. Appetite Loss - Anorexia Nervosa
    

59. Controlled Studies
    

60. Dronabinol
    

61. •      Gross H, Ebert MH, Faden VB, Goldberg SC, Kaye WH, Caine ED, Hawks R, Zinberg N. A double-blind trial of delta 9-tetrahydrocannabinol in primary anorexia nervosa. Journal of Clinical Psychopharmacology 1983;3(3):165-171.
    

62.  
    

63. Appetite Loss – COPD
    

64. Uncontrolled Studies
    

65. Dronabinol
    

66. •     Bergmann K-C. [Dronabinol, a possible new therapeutic option in patients with COPD and pulmonal cachexia] [Article in German]. Abstract, 2005 Conference of the German Society for Pneumology, 17 March 2005, Berlin.
    

67.  
    

68. Appetite Loss – Healthy Subjects
    

69. Controlled Studies
    

70. Cannabis (smoked)
    

71. •     Foltin RW, Fishman MW, Brady JV. Behavioral analysis of marijuana effects on food intake in humans. Pharmacology, Biochemistry and Behavior 1986;25:577-582.
    

72. •     Foltin RW, Fischman MW, Byrne MF. Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory. Appetite 1988;11(1):1-14.
    

You will find scientific information on most of the studies at Database on Clinical Studies and Case Reports.

1. 
   

2. •Improvement of symptoms or positive evaluation by authors
   

3. •No relevant change of symptoms or negative evaluation by authors
   

4. •Deterioration of symptom

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