1. Intraocular Pressure - Glaucoma
   

2. Controlled Studies
   

3. Cannabis (smoked)
   

4. •      Crawford WJ, Merritt JC. Effects of tetrahydrocannabinol on arterial and intraocular hypertension. International Journal of Clinical Pharmacololgy and Biopharmacy 1979;17(5):191-196.
   

5. •      Merritt JC, Crawford WJ, Alexander PC, Anduze AL, Gelbart SS. Effect of marihuana on intraocular and blood pressure in glaucoma. Ophthalmology 1980;87(3):222-8. 
   

6. Dronabinol
   

7. •      Tomida I, Azuara-Blanco A, House H, Flint M, Pertwee RG, Robson PJ. Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study. J Glaucoma 2006;15(5):349-353.
   

8. •Cannabidiol
   

9. •      Tomida I, Azuara-Blanco A, House H, Flint M, Pertwee RG, Robson PJ. Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study. J Glaucoma 2006;15(5):349-353.
   

10.  
    

11. Uncontrolled Studies
    

12. Cannabis (smoked)
    

13. •     Hepler RS, Frank IM, Petrus R. Ocular effects of marijuana smoking. In: Braude MC, Szara S, eds. The pharmacology of marihuana. Raven Press: New York: 1976;815-828.
    

14.  
    

15. Case Reports, Surveys
    

16. Cannabis (smoked)
    

17. •     Russo EB, Mathre ML, Byrne A, Velin R, Bach PJ, Sanchez-Ramos J, et al. Chronic cannabis use in the Compassionate Investigational New Drug Program: An examination of benefits and adverse effects of legal clinical cannabis. J Cannabis Ther 2002;2(1):3-57.
    

18.  
    

19. Topical Administration
    

20. Dronabinol
    

21. •      Merritt JC, Perry DD, Russell DN, Jones BF. Topical delta 9-tetrahydrocannabinol and aqueous dynamics in glaucoma. Journal of Clinical Pharmacololgy 1981;21(8-9 Suppl):467S-471S.
    

1. Intraocular Pressure - Healthy Subjects
   

2. Controlled Studies
   

3. Dronabinol
   

4. •      Cooler P, Gregg JM. Effect of delta-9-tetrahydrocannabinol on intraocular pressure in humans. Southern Medical Journal 1977;70(8):951-954.
   

5. •      Jones RT, Benowitz N, Herning RI. The clinical relevance of cannabis tolerance and dependence. Journal of Clinical Pharmacology 1981;21:143S-152S.
   

6. •      Levitt M, Wilson A, Bowman D, Kemel S, Krepart G, Marks V, Schipper H, Thomson G, Weinerman B, Weinerman R. Physiologic observations in a controlled clinical trial of the antiemetic effectiveness of 5, 10, and 15 mg of delta 9-tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications. J Clin Pharmacol 1981;21(8-9 Suppl):103S-109S.
   

7.  Delta-9-THC, Delta-8-THC, 11-OH-THC, CBD, CBN
   

8. •      Perez-Reyes M, Wagner D, Wall ME. Davis KH. Intravenous administration of cannabinoids and intraocular pressure. In: Braude MC, Szara S, ed. Pharmacology of marihuana. New York: Raven Press, 1976;829-832.
   

9.  
   

10. Uncontrolled Studies
    

11. Dronabinol
    

12. •      Plange N, Arend KO, Kaup M, Doehmen B, Adams H, Hendricks S, Cordes A, Huth J, Sponsel WE, Remky A. Dronabinol and retinal hemodynamics in humans. Am J Ophthalmol 2007;143(1):173-4.
    

13. Cannabis (smoked)
    

14. •      Hepler RS, Frank IM. Marihuana smoking and intraocular pressure. Journal of the American Medical Association 1971;217:1392.
    

15. •      Flom MC, Adams AJ, Jones RT. Marijuana smoking and reduced intraocular pressure in human eye: Drug action or epiphenomenon? Investigative Ophthalmology 1975;14:52-55.
    

16. •      Hepler R S, Frank I M, Petrus R. Ocular effects of marijuana smoking. In: Braude MC, Szara S, eds. The pharmacology of marihuana. New York: Raven Press, 1976;815-828.
    

1. Night Vision
   

2. Controlled Studies
   

3. Dronabinol
   

4. •     Russo EB, Merzouki A, Molero Mesa J, Frey KA, Bach PJ. Cannabis improves night vision: A pilot study of dark adaptometry and scotopic sensitivity in kif smokers of the Rif Mountains of Northern Morocco. J Ethnopharmacol 2004;93(1):99-104.
   

5.  
   

6. Uncontrolled Studies
   

7. Cannabis (smoked)
   

8. •      Russo EB, Merzouki A, Molero Mesa J, Frey KA, Bach PJ. Cannabis improves night vision: A pilot study of dark adaptometry and scotopic sensitivity in kif smokers of the Rif Mountains of Northern Morocco. J Ethnopharmacol 2004;93(1):99-104.  
   

You will find scientific information on most of the studies at Database on Clinical Studies and Case Reports.

1. 
   

2. •Improvement of symptoms or positive evaluation by authors
   

3. •No relevant change of symptoms or negative evaluation by authors
   

4. •Deterioration of symptoms

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